BBC Radio 1's comedy Dave from the Chris Moyles show and Mark Chapman from the Scott Mills show will be running a mile at each premier league club to raise money for charity.
Starting tomorrow, the boys will be working their way round each club in England and Scotland before ending up in London for a spectacular finale ahead of the Sport Relief TV show on 14 March.
Moyles will be following their progress each morning on the breakfast show and the pair will have run over 30 miles each.
Comedy Dave says: "We get to spend a week on the road, having a laugh, meeting some top people and collecting money for a very good cause. With the exception of the running bit, I think it will be great."
Chappers adds: "Two years ago Sport Relief changed my views on life in general by taking me to India. I have never seen such deprivation in my life – no-one on earth should have to live like this.
"Any amount you can spare will help projects both in this country and abroad, with your help we can give them hope for the future."
