IPC, the owner of NME Radio is pulling the plug on the station, removing the service from Digital TV and radio platforms.
The station was operated by DX Media since 2008 as a spin off to the magazine of the same name.
The station was broadcast on Digital One, Sky, Virgin, Freesat and via its new iPhone app.
NME publishing director Paul Cheal told Media Guardian: "We have enjoyed a great working relationship with DX Media and we would like to thank them for all the excellent work that has gone into NME Radio.
"Meanwhile, we will continue to develop ways in which NME's audience can engage with both audio and content utilising our in-house studio facilities whilst maintaining an online music service via our award-winning music website nme.com."