Ken Livingstone and David Mellor are teaming to host a new Saturday show, whilst Petrie Hosken, Iain Dale and Nick Abbot gain extra slots.
The changes are part of the new autumn and spring schedule for the London speech station.
Gino D’Acampo also joins the line-up to host new live show from his kitchen. He'll be on-air every Sunday from 3pm.
Also at the weekend, the former Mayor of London Ken Livingstone teams up with former Conservative cabinet minister David Mellor for a new Saturday morning programme from 10am till 1pm.
Petrie Hosken joins the daytime line-up to present the weekday afternoon show, and blogger Iain Dale takes over from Petrie to host the weekday evening show.
Nick Abbot starts a new Friday late show, in addition to his Saturday night show.
LBC 97.3’s Programme Director Jonathan Richards said: “These schedule changes demonstrate the steady evolution of London’s biggest conversation. We are constantly looking to bolster our line-up with quality broadcasters who are knowledgeable, opinionated and compelling to listen to.”