Changes at 5 live include Phil Williams replacing Tony Livsey on lates, and Question Time being simulcast from BBC 1.
It’s the first major change under new Controller Jonathan Wall who wants to increase emphasis on news and political output.
From 16 May, Question Time with David Dimbleby will air on both TV and radio, during a show with Stephen Nolan and John Pienaar having a live radio debate on the topics addressed in the show.
Then from early September, Sunday politics programme ‘Pienaar’s Politics’ moves to 10am Sunday morning.
Tony Livsey, who hosts the Late Show will move to weekend breakfast, co-hosted by Eleanor Oldroyd on Saturday and by BBC Radio Manchester’s Sam Walker on Sunday. Gary Richardson’s Sportsweek will move to a later slot of 9.00am.
Jonathan Wall said: “We want to create some really exciting new shows that showcase our news journalism – from a dynamic Thursday night around Question Time to an agenda setting Sunday morning show.
“I believe all of these changes will make us even better and more distinctive and I know I’ve got great presenters and programme teams in place looking forward to creating something special for our listeners.”