The Saturdays, Union J, Rizzle Kicks, Tom Odell and The Vamps are to perform at Clyde’s 40th birthday concert in December.
The station says it will be its biggest ever gig, partnering with ROX Diamonds & Thrills to bring these and even more acts to the city.
Cash for Kids will also be benefitting from a special pre-concert event at The Hydro, with all profits going to the charity.
George Bowie, breakfast show host for 102.5 Clyde 1, said: “While Clyde 1 LIVE 2013 has been planned for some time now it is when the first acts are confirmed that the whole thing really comes to life.
“The Saturdays, Union J, Rizzle Kicks, Tom Odell and The Vamps represent some of the UK’s best and most current live music and are a really diverse mix which ensures there really will be something for everyone on the night.
“Our biggest challenge might be accommodating everyone who wants to join us for this unique night of live music and celebration so I’d encourage listeners to snap up their tickets quickly.
“We’ll announce our next wave of acts very soon and from the names I am hearing we are talking to Clyde 1 LIVE 2013 is set to go off the scale. I can’t wait.”